Search results for "Diaryl ether"

showing 2 items of 2 documents

Isolation, structure elucidation, and biological evaluation of the unusual heterodimer chrysoxanthone from the ascomycete IBWF11-95A

2009

Chrysoxanthone, an unusual heterodimer of blennolide A and 2-hydroxychrysophanol linked through a diaryl ether bridge, was isolated from mycelia of the ascomycete IBWF11-95A grown in submerged culture. Its structure was elucidated by two-dimensional NMR spectroscopy. The metabolite shows antibacterial activity against different species with MIC values between 2.5 and 20 μg/mL while also inhibiting the growth of several fungi.

Diaryl etherStereochemistryMetaboliteOrganic ChemistryNuclear magnetic resonance spectroscopyIsolation (microbiology)Biochemistrychemistry.chemical_compoundchemistryMic valuesDrug DiscoveryAntibacterial activityMyceliumBiological evaluationTetrahedron Letters
researchProduct

Screening of ligands for the Ullmann synthesis of electron-rich diaryl ethers

2012

In the search for new ligands for the Ullmann diaryl ether synthesis, permitting the coupling of electron-rich aryl bromides at relatively low temperatures, 56 structurally diverse multidentate ligands were screened in a model system that uses copper iodide in acetonitrile with potassium phosphate as the base. The ligands differed largely in their performance, but no privileged structural class could be identified.

chemistry.chemical_classificationC–O bond formationDenticityBase (chemistry)catalysisArylOrganic Chemistrynucleophilic aromatic substitutiondiaryl ethersUllmann-type couplingCombinatorial chemistryFull Research PaperCatalysislcsh:QD241-441Chemistrychemistry.chemical_compoundchemistrylcsh:Organic chemistryNucleophilic aromatic substitutionPotassium phosphateOrganic chemistrylcsh:QAcetonitrilelcsh:ScienceCopper iodideBeilstein Journal of Organic Chemistry
researchProduct